Anthracycline therapy is associated with an increase in the risk for developing heart failure with significant associated morbidity and mortality 1. Protective effect of irbesartan against doxorubicininduced. Clinical features and outcomes of bloodstream infections caused by new delhi metalloi. The mechanisms of doxorubicin induced cardiotoxicity remain incompletely understood. Yiqi fumai lyophilized injection attenuates doxorubicin. Protective effects of khamira abresham hakim arshad wala, a. Hypoalbuminemia and hypercholesterolemia appeared after the doxorubicin injection. The interplay between genetic background and sexual. Sexual dimorphism of acute doxorubicininduced nephrotoxicity in. Renal toxicities seen with several classes of molecularly targeted and biologic agents, renal toxicity associated with drugs that target the vascular endothelial. Doxorubicininduced nephrotoxicity comprises a state of progressive. Biochemical evaluations of the effects of the sulfhydrylcontaining angiotensinconverting enzyme inhibitor captopril on the nephrotoxicity induced by doxorubicin in normal rats were carried out. The aim of this study was to investigate the effects of pravastatin ps on doxorubicin induced nephrotoxocity. Thus, exploration of effective drug targets or active lead compounds against dox induced organ damage is necessary.
Dioscin shows active effects against renal ischemiareperfusion injury and lipopolysaccharide induced inflammatory kidney injury, however, little is known concerning the role of it on doxorubicin dox induced nephrotoxicity. Sexual dimorphism of acute doxorubicininduced nephrotoxicity. Effect of plantago major extract on doxorubicininduced. Thyme oil and thymol abrogate doxorubicin induced nephrotoxicity and cardiotoxicity in wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms osama m. Doxorubicin dox is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in. Doxorubicin dox is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Zaky department of pharmacology and toxicology, faculty of pharmacy girls, alazhar university, cairo, egypt. Doxorubicin dox, a common chemotherapeutic drug, has been reported to induce numerous toxic side effects including renaltoxicity. Antitumor activity, cardiotoxicity, and nephrotoxicity induced by doxorubicin were studied in loumwsl inbred rats each bearing a transplantable sol we use cookies to enhance your experience on our website. Protective effect of irbesartan against doxorubicin induced nephrotoxicity in rats. Dox injection exerted a protective effect against doxinduced kidney. Doxorubicin dox, a wellknown chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal toxicity. A medicinal and edible formula yh0618 ameliorates the. Protective effects of olmesartan and lcarnitine on doxorubicin induced cardiotoxicity in rats.
Prevention of van induced nephrotoxicity without decreasing efficacy is a highly desirable objective in treatment of mrsa induced crbsi. This results in both systolic and diastolic dysfunction. Protective effects of dioscin against doxorubicininduced. Quercetin attenuating doxorubicin induced hepatic, cardiac and renal toxicity in male albino wistar rats sudhanshu jambhulkar, swathi deshireddy, dinesh babu jestadi and latha periyasamy department of biochemistry and molecular biology, school of life sciences, pondicherry university, puducherry 605014, india abstract doxorubicin dox is.
Alleviation of doxorubicininduced nephrotoxicity by. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. Comparison of nephrotoxicity of pirarubicin and doxorubicin. Phoenix dactylifera protects against doxorubicininduced. Female rodents have been shown to be protected against several features of dox induced nephrotoxicity. A single dose of doxorubicin 15 mg kg1 which caused nephrotoxicity was manifested biochemically by the elevation of serum urea after 24 and 48 h. Protection from doxorubicininduced nephrotoxicity by clindamycin. Protective effects of madecassoside against doxorubicin induced. Elucidating the timedependent changes in the urinary.
Sep, 2019 doxorubicin dox, an antitumor antibiotic, has therapeutic effects on many kinds of tumors. This study is designed to determine the effect of phoenix dactylifera extract pde on dox induced. Weinberg, subcellular effects of adriamycin in the heart. Rutin protects against neuronal damage in vitro and. Effect of pentoxifylline against doxorubicininduced nephrotoxicity in rabbits d int.
Possible protective effect of diacerein on doxorubicininduced. Protective effects of ltheanine against doxorubicin induced nephrotoxicity in rats. B 51 and caspase3 52 were increased significantly in doxorubicin induced nephrotoxicity. Nephrotoxicity is one of the complications the use of doxorubicin dxr which may be caused by the formation of free radicals.
Moreover, the effect of qur in the presence of dox on the cell viability of four different. Mar 15, 2016 doxorubicin dox is a very effective anticancer medication that is commonly used to treat hematological malignancies and solid tumors. Effect of captopril on doxorubicininduced nephrotoxicity in. Protective effects of ltheanine against doxorubicininduced. Molecular pharmacology profile of anthracycline antibiotic adriamycin doxorubicin includes inhibition of nucleic acid synthesis and cytochrome c oxidase, intercalation of dna, and generation of reactive oxygen species, which account not only for its oncolytic effects but also for the depression of the bone marrow and development of cardiomyopathy and nephropathy. Protection from doxorubicininduced nephrotoxicity by. Doxorubicin dox is an important anticancer drug used widely in the treatment of leukemia and lymphoma. Alleviation of doxorubicininduced nephrotoxicity and hepatotoxicity by chrysin in wistar rats article pdf available in toxicology mechanisms and methods 235 december 2012 with 1,434 reads. Meeting abstract open access protective effects of berberine. Dioscin, one natural product, has potent effects against dox induced renal injury and. Doxorubicin, isolated from the bacterium streptomyces peucetius var. Dox is one of the key chemotherapeutic drugs for cancer treatment, but its. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Pdf alleviation of doxorubicininduced nephrotoxicity.
In addition, correlation analysis and molecular docking techniques were used to verify the. Doxorubicin is an anthracycline antibiotic with antineoplastic activity. In experimental studies, female animals have been shown to be protected against dox induced cardiotoxicity. Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. Protective effects of molsidomine against doxorubicininduced renal. Oct 17, 2012 doxorubicin, a very potent and often used anticancer drug, is largely limited due to the doserelated toxic effects. However, dox can produce some serious side effects that limit its clinical application.
The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be nephrotoxic to humans. Protective effects of berberine on doxorubicininduced. The clinical usefulness of the doxorubicin has been precluded by its marked cardiotoxicity. By continuing to use our website, you are agreeing to our use of cookies. This preliminary study was designed to investigate the ameliorative effects of methanolic leaf extract of clerodendrum volubile mecv against dox induced nephrotoxicity in rats. In the present study, in vivo test of dox induced nephrotoxicity in rats and in vitro model in nrk52e cells were developed. Effects of quercetin on kidney injury induced by doxorubicin.
Melatonin ameliorates the drug induced nephrotoxicity. Antitumor effect, cardiotoxicity, and nephrotoxicity of. Nephrotoxicity and ototoxicity of aztreonam versus. In the present study, the detection of urinary timedependent changes in doxorubicin induced nephrotoxicity was carried out using 1 h nmrbased metabolomics, and the molecular mechanism was further elucidated based on the involved metabolic pathway. The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin.
Protective effects of ltheanine against doxorubicininduced nephrotoxicity in rats. Nevertheless, dox is known to have cardiotoxic effects that may lead to cardiac dysfunction and failure. The anthracyclines and related compounds doxorubicin, daunorubicin, idarubicin, epirubicin, and the anthraquinone mitoxantrone are among the chemotherapeutic agents implicated in cardiotoxicity. Doxorubicin induces cardiotoxicity through upregulation of. Phytomodulatory potential of lycopene from lycopersicum. Pdf alleviation of doxorubicininduced nephrotoxicity and.
Protective effects of berberine on doxorubicin induced nephrotoxicity in mice xiaoyan zhao, nannan tong from 2012 sinoamerican symposium on clinical and translational medicine sasctm shanghai, china. Mar 16, 2017 doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. Lactamaseproducing enterobacterales during a regional outbreak. The present study aimed to assess the protective effect of proanthocyanidins pas against dox.
The suitability of dox is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. The rats were divided into control, nad alone, doxorubicin 20 mgkg, i. Doxorubicin induced cardiomyopathy typically results in dilated cardiomyopathy, with all four cardiac chambers being enlarged. The present study investigated whether berberine, a natural product alkaloid, can reduce the renal injury induced by doxorubicin. Boswellic acids ameliorate doxorubicininduced nephrotoxicity in. The aim of this study was to investigate the effects of nicotinamide nad, an antioxidant agent, against nephrotoxicity induced by doxorubicin dxr. Yiqi fumai lyophilized injection attenuates doxorubicininduced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis yue gu, a aichun ju, b bingjie jiang, a jingze zhang, c shuli man, d changxiao liu e and wenyuan gao a. Effect of pravastatin on levels of filtration slit diaphragm. Doxorubicin is one of the most active cytotoxic agents in current use. The mechanisms of doxorubicininduced cardiotoxicity. Dec 18, 2019 this study was performed to examine whether clindamycin could protect against doxorubicin dox induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for this protective effect. Alleviation of doxorubicininduced nephrotoxicity and hepatotoxicity by chrysin in wistar rats. Protective effect of proanthocyanidins against doxorubicin.
Doxorubicin dox exerts toxic effects in several organs particularly kidney. Protective effects of olmesartan and lcarnitine on. A novel hybrid cytokine il233 mediates regeneration following. Several studies have reported that expressions of inos 10, 49, tnf. Quercetin attenuating doxorubicin induced hepatic, cardiac. Jun 16, 2011 nephrotoxicity is one of the important side effects of anthracycline antibiotics. A novel hybrid cytokine il233 mediates regeneration. Although several in vitro and in vivo approaches have been proposed to reduce vaninduced renal toxicity, such as antioxidants or erythropoietin 1, 7, 11, 14, it is unclear whether such approaches would. Ramalingayya, grandhi venkata and cheruku, sri pragnya and nayak, pawan g and kishore, anoop and shenoy, rekha r and rao, mallikarjuna c and krishnadas, nandakumar 2017 rutin protects against neuronal damage in vitro and ameliorates doxorubicin induced memory deficits in vivo in wistar rats. The aim of present study was to determine the protective effects of quercetin against doxorubicin induced kidney injury with light microscopy. Protective effects of madecassoside against doxorubicin induced nephrotoxicity in vivo and in vitro.
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